Bioengineers create pathway to personalized medicine


Cornell University


Engineering cellular biology, minus the actual cell, is a growing area of interest in biotechnology and synthetic biology. Unfortunately, a long-standing gap in cell-free systems is the ability to manufacture glycosylated proteins – proteins with a carbohydrate attachment. DeLisa and Jewett are co-senior authors of Single-pot Glycoprotein Biosynthesis Using a Cell-Free Transcription-Translation System Enriched with Glycosylation Machinery, published July 12 in Nature Communications. The resulting extracts enabled a simplified reaction scheme, which the team has dubbed cell-free glycoprotein synthesis (CFGpS). A major advance of this work is that our cell-free extracts contain all of the molecular machinery for protein synthesis and protein glycosylation, Stark said.


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