How DNA alarm-system works

Lomonosov Moscow State University

DNA repair consists of enzymes which find the damaged DNA and repair it before the replication. Some of them recognize the damaged bases and give signals to the other enzymes, which repair the DNA. Scientists used to think that ATM exclusively recognizes DNA double-strand breaks (DSBs). The concept of the cellular function lies in the prevention of DNA double-strand break’s formation, – Svetlana V. Khoronenkova said, – We now understand that ATM recognizes and is activated in response to DNA single-strand breaks (SSBs). This leads to a delay in the DNA replication, giving a cell more time to repair.

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