Imaging of scar tissue formation: Noninvasive magnetic resonance imaging of lung fibrogenesis with an amino acid targeted probe


Wiley


Organs respond to injuries with the formation of new fibrous tissue, which can result in scarring. This process called fibrogenesis can now be monitored noninvasively on a molecular level, as American scientists report in the journal Angewandte Chemie. Natural wound healing and tissue injury involves the formation of collagen-based fibrous tissue to close the wound. To monitor this process, Peter Caravan and collaborators from Massachusetts General Hospital and Harvard Medical School, USA, sought a molecular probe that could specifically recognize the components involved in fibrogenesis. They have created a functionalized gadolinium chelate as a probe for magnetic resonance imaging (MRI).


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