Molecular basis for memory and learning: Brain development and plasticity share similar signalling pathways
Goethe-Universität Frankfurt am Main
Learning and memory are two important functions of the brain that are based on the brain’s plasticity. The Frankfurt scientists now discovered that three key molecules are involved in this regulation: GRIP1, ephrinB2 and ApoER2, the latter being a receptor for the signalling molecule Reelin. These results are fascinating since it has been known for years that ephrinB2 as well as Reelin are essential for the development of the brain explains Amparo Acker-Palmer. Both, ApoER2 and ephrinB2 molecules have been linked to the development of Alzheimer’s, although the mechanisms of action are not clear yet, says Amparo Acker-Palmer. With our research we not only discovered new interactions of key molecules for the regulation of learning and memory but also shed light on potential new therapeutic targets for the treatment of Alzheimer’s disease.