Non-aqueous solvent supports DNA nanotechnology

Georgia Institute Of Technology

Researchers at the Georgia Institute of Technology have now shown that they can assemble DNA nanostructures in a solvent containing no water. With this work, we have shown that DNA nanostructures can be assembled in a water-free solvent, and that we can mix water with the same solvent to speed up the assembly. The solvent system developed at Georgia Tech adds a new level of control over DNA assembly. Not only did the glycholine assemble the DNA structure at a relatively low temperature, but it also avoided kinetic traps, intermediate structures that are stable, but not the desired structure, Gállego said. The research on water-free solvents grew out of Georgia Tech research into the origins of life.

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